| Register now for this free webinar and learn about new technology that leverages your mass spec devices for rapid detection of counterfeit drugs. This webinar will be presented by Prof. Facundo Fernandez of Georgia Institute of Technology. Prof. Fernandez' most notable work is in the detection of counterfeit antimalarial tablets, which will be discussed here among other examples.
Abstract Although more rampant in the developing world, counterfeit drugs know no borders, and cases are constantly uncovered in both developed and developing countries. For example, in June 2010 the US Food and Drug Administration issued a warning of online pharmacies selling a fake version of the flu treatment Tamiflu (oseltamivir) that could be dangerous to people allergic to penicillin. The so called "generic Tamiflu" sold online was found to contain cloxacillin, a penicillin that could cause unexpected and inexplicable severe allergic reactions. In January 2010, INTERPOL released the results of a large multi-country police operation targeting the manufacture and distribution of counterfeit medicines in SE Asia named "STORM II". This operation resulted in more than 30 arrests and the seizure of 20 million fake and illegal medicines. It also led to the closure of more than 100 pharmacies and illicit drug outlets. In this webinar, we will showcase the use of Desorption Electrospray Ionization-Mass Spectrometry (DESI-MS) for the qualitative and quantitative analysis of solid pharmaceutical samples, with specific emphasis on how "unknown knowns" can be identified, how active ingredients can be quantified with or without the use of internal standards, and how DESI imaging MS can be used for investigating product homogeneity. |
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