DESI, MALDI and Histochemistry on the same sample

Eberlin et al. have developed methods for performing DESI, MALDI and H&E staining on the same tissue sample.  The workflow begins with DESI imaging using non-destructive solvents, then matrix application and MALDI analysis, followed by H&E staining.  While this new procedure was implemented on different instruments in separate laboratories, the concept can be advantageously applied in dual source systems such as Waters Synapt G2 or the Bruker SolariX.