New Publication: Development of Stereotactic Mass Spectrometry for Brain Tumor Surgery

By:  Agar, Nathalie YR PhD; Golby, Alexandra J MD†; Ligon, Keith L MD, PhD; Norton, Isaiah BS; Mohan, Vandana PhD; Wiseman, Justin M PhD; Tannenbaum, Allen PhD; Jolesz, Ferenc A MD

Neurosurgery:

February 2011 - Volume 68 - Issue 2 - pp 280-290

doi: 10.1227/NEU.0b013e3181ff9cbb

 

Summary:

By integrating a 3-dimensional navigation system with an ultrasonic surgical probe, the authors obtained image-registered surgical specimens and subjected those specimens to intraoperative molecular analysis analysis by DESI-MS and MS/MS.The mass spectral results were then validated against standard histopathology.  The results of this proof of concept study showed correlation between lipid constitution of the tumor mass and malignancy.